Quercetin A naturally-occurring flavonoid with antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, immunomodulatory, antihypertensive, anti-allergy, neuroprotective, and antimicrobial properties. A THREAD 🧵
Quercetin is a flavonoid found abundantly in nature. It shows a relatively higher bioavailability than other phytochemicals and exists in a variety of plant-based foods such as capers, grapes, berries, cherries, apples, citrus fruits, buckwheat, kale, tomatoes, and black tea.
Quercetin is also known to be present in herbs such as dill, certain varieties of tea, and wine, as well as in various medicinal plants such as ginkgo, American elderberry, and Hypericum species.
Diabetic? Well quercetin may help metabolically. It possesses the ability to increase insulin sensitivity, reduce insulin resistance, promote the proliferation of pancreatic cells, maintain the mass and function of diabetic pancreatic cells.
Quercetin has also shown potential in alleviating and/or protecting against diabetic-related diseases such as liver, kidney and eye disorders.
One trial of 24 diabetics taking a single dose of 400 mg of quercetin showed that this flavonoid has the ability to reduce the spike in blood sugar levels after consuming sugar.
But another study, where the study group took 250 mg of quercetin four times a day for eight weeks, showed improved antioxidant status in patients but no other significant effect on blood sugar control or lipid profile.
Quercetin has shown some cardioprotective potential. In one study, quercetin and its derivative epicatechin were shown to improve endothelial function through modulation of the blood nitric oxide concentration and enhance vascular activity.
Quercetin has also shown the ability to prevent abnormal enlargement of the heart, reduce blood pressure in patients with high blood pressure, and reduce markers of inflammation in heart disease patients.
Quercetin has also shown neuroprotective potential, being able to inhibit amyloid-β aggregation; reduce the formation of tau proteins and inhibit acetylcholinesterase.
It is thought that the structural shape of quercetin may play an important role in amyloid-β aggregation inhibition and disrupt the mature protein fibrils by forming bonds with Aβ.
There have also been a plethora of in vitro studies on various cancer cell lines, including lung, ovarian, nasopharyngeal, breast, leukaemia, prostate, bone, colon, and skin, that show some anti-cancer potential of quercetin.
Quercetin and its derivatives have also shown antiviral potential against various viruses, including hepatitis B and C, various herpesviruses, orthomyxoviruses like influenza viruses, retroviruses like HIV, coronaviruses, and more.
Its promising antiviral effects are due to its ability to inhibit various enzymes such as polymerases, reverse transcriptases, and proteases, suppress DNA gyrase, and bind viral capsid proteins.
And with regards to SARS-CoV-2, the literature reveals that quercetin may exhibit anti-COVID-19 activity via its inhibitory effect on the expression of the human ACE2 receptors and certain enzymes of the virus.
In one study of 429 patients with COVID-19, the use of quercetin, vitamin C, and bromelain in combination showed improvements in the recovery rate and blood parameters of those who took the combination.
And a smaller study revealed that supplementing with quercetin at the start of illness shortened the timing of molecular test conversion from positive to negative, reducing at the same time symptoms severity and negative predictors of COVID-19.
Before you scroll further, I'd like to let you know that if you have been finding my threads helpful, then all the information on them, including quercetin, can all be found in one place, the book 👇🏾 Click on the link to find out more.
In a study of 25 participants given a daily oral co-supplementation of 168 mg curcumin, 260 mg quercetin, and 9 mcg (360 IU) of vitamin D3. Authors note: “The co-supplementation of CQC may possibly have a therapeutic role in the early stage of COVID-19 infection including...
...speedy negativization of the SARS-CoV-2 RT-PCR test, resolution of acute symptoms, and modulation of the hyperinflammatory response."
Quercetin has shown other useful properties such as attenuating the harmful effects of arsenic, protecting against glyphosate toxicity, and helping with post-exercise immunodeficiency.
But it doesn't end there, research has also shown this flavonoid to have anti-parasitic properties, be able to promote autophagy, be able to chelate iron, have the ability to inhibit the formation of prion amyloid fibrils,
as well as turning amyloid fibrils into protease-sensitive structurally loose harmless forms; have the ability to clear senescent cells (similar to fisetin); and enhance the effects of other molecules like zinc and resveratrol when used in combination.
The dosages of quercetin used are in the range of 12.5 to 25 mg per kg body weight, which translates to a range of 1,136-2,272 mg daily consumption of quercetin when taken alone.
One may theoretically gain benefits at lower dosages if quercetin is supplemented with other flavonoids such as resveratrol, genistein, or green tea catechins, as these increase the potency synergistically.
If you enjoyed that, feel free to check out my other threads. This one is on Nigella sativa.
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These are the 55 supplements/therapies I have included in the book that may help with post-shot injuries.
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They cover a range of physiological processes.
This is not intended to be taken as medical advice.
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A thyroid warning with quercetin.
I was taking Quercitin. Also Hawthone, K2 and Olive Leaf. I stopped all as my thyroid number drastically spiked. When I found out I did a deeper dive into reactions of supplements and found Quercetin is problematic with levothyroxine.
— Truly, truly (@cindy_lehn) March 9, 2023
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